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this post was submitted on 24 Jul 2025
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You can't outrun physics: calories in, calories out. The universe doesn't care about your genetics, doesn't care about your physical or mental health issues - it obeys the law of the land. If you burn more than you consume, you lose weight. If you consume more than you burn, you gain weight.
It's a bit more nuanced than that
The big secret is hormones, don't interfere with your hormones and the body will self regulate body composition to optimal (lose weight if your obese).
[Paper] The Carbohydrate-Insulin Model of Obesity - Beyond “Calories In, Calories Out” - 2018
TLDR - Eating sugar and carbohydrates forces blood glucose levels to rise (within minutes), elevated blood glucose forces insulin to rise (to reduce blood glucose), elevated insulin forces the body to go into anabolic (gain weight) state. Basically you can't lose any fat while your insulin is high, so every time someone eats a bunch of sugar or carbohydrates with a meal/snack they are putting a 2-4 hour pause on any fat loss.
Also the laws of thermodynamics your using in your It's simple CICO statement require a closed system without mass transfers. Humans are open systems, eating, pooping, breathing, peeing, drinking... All the time. So yes CICO is technically correct, it's not clinically helpful to most people.