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Nuclear fusion reactor in South Korea runs at 100 million degrees C for a record-breaking 48 seconds
(www.livescience.com)
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ELI5 would be huge magnets. If there is something that melts everything humanity ever created and knows of, keep it away from everything. But it is a real problem, instability in the plasma leads to the need for better materials.
vacuum for isolation. Magnets, so the plasma stays in the middle and won't touch the walls. Microwaves to heat it up.