Essentially they find that interleukin-6 (IL-6) a well-known inflammatory signal is important to neuronal lymphatics which are key to brain waste removal. Frankly, not too surprising imo but they do drill it down very well to what cells are effectors/affected. They use a drug, PLX5622, to inhibit this IL-6 activity and see significant improvement to mice where neuronal inflammation had been induced, genetically or surgically.

I'm very sleepy so didn't read into any side-effects they notice or discuss as possibilities.

[–] charade_you_are@sh.itjust.works 7 points 2 weeks ago

I wish my brain could take a shit but it don't sleep no good

[–] Onomatopoeia@lemmy.cafe 5 points 2 weeks ago* (last edited 2 weeks ago) (1 children)

So pooping improves your memory? 😁

[–] MonkderVierte@lemmy.ml 1 points 2 weeks ago

No, drinking more water, no joke.

[–] Spacehooks@reddthat.com 4 points 2 weeks ago

Brain needs a good wash

[–] I_Fart_Glitter@lemmy.world 3 points 2 weeks ago

Brain pooping (waste removal via cerebrospinal fluid).