Advances in detection technology have led to an exponential growth in data, necessitating innovative and efficient analysis methods. This problem is exacerbated by the large variety of possible forms an extraterrestrial signal might take, and the size of the multidimensional parameter space that must be searched. It is then made markedly worse by the fact that our best guess at the properties of such a signal is that it might resemble the signals emitted by human technology and communications, the main (yet diverse) contaminant in radio observations. We address this challenge by using a combination of simulations and machine learning methods for anomaly detection.