Nah, ozempic and Co change sugar absorption and satiation. People on it primarily eat way less instantly, apparently they just feel full and don't feel any desire to keep going. It also slows sugar absorption which is why it helps manage diabetes, so that might also play some role

So far we've found it thickens the intestinal lining and significantly messes with the reward pathways, we're not sure what the long term effects could be. It seems like at best, you basically have to stay on it indefinitely or regain the weight (which is true of current weight loss drugs)

[+] peopleproblems@lemmy.world 4 points 9 months ago (1 children)

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[–] theneverfox@pawb.social 4 points 9 months ago (1 children)

As for the thickening of the bowel, I have no idea, but it seems like the bowel movement speed and that are both side effects

And as for making it stick - here's my take. Animals don't become obese... Except when you feed them highly processed food. There's also a theory floating around that seed oils drive sugar cravings, and the fat they release does the same thing

So my advice would be this - use this opportunity to fix this. If you burn the old fat, get rid of your sugar cravings, and eat better food you might be able to fix your system in a way people mostly only do by moving to somewhere with better food culture for years

Avoid processed food and seed oils as much as possible. Take advantage of the time you have on it, and stack the deck in your favor while you can

[–] mojofrododojo@lemmy.world 3 points 9 months ago

I have no doubt ads for 'ozempic/watevgy class action lawsuits' are in our future. anytime I see a drug take off like that I assume the side effects will be interesting.

[–] hogmomma@lemmy.world 3 points 9 months ago

Alli block fat absorption, I don't think the two you mentioned do.

[–] werefreeatlast@lemmy.world 5 points 9 months ago (1 children)

One of your breasts will grow by 3 inches in diameter. The other gets a much larger and more sensitive second nipple towards the very top of your chest at the base of your neck completely visible regardless of how conservative you dress like.

[–] werefreeatlast@lemmy.world 5 points 9 months ago

The drug name is ofcourse, "Niplovyadalimumaboxidazeoicbenzoplastaze" it's fairly simple to draw.

[–] Addv4@lemmy.world 2 points 9 months ago

Oh, it's fine, the brain is a different kind of fat! /s

[–] Tronn4@lemmy.world 24 points 9 months ago (1 children)

I think it's called exercise. I've seen a meme about exercise. Do not recommend

[–] APassenger@lemmy.world 14 points 9 months ago (2 children)

People hurt themselves that way. Play it safe, walk slowly to the fridge and back.

[–] piecat@lemmy.world 2 points 9 months ago (1 children)

I always feel insulted when I go to the fridge for a snack and my smart watch says "nice job staying active"

[–] APassenger@lemmy.world 1 points 9 months ago

We should be able to respond with varying degrees of enthisiasm: Thank you! Alright then. Hmph Meh Eff off.

You know... For sentiment analysis.

[–] Tronn4@lemmy.world 1 points 9 months ago

On it!

[–] Sterile_Technique@lemmy.world 14 points 9 months ago (2 children)

Kinda reminds me of dinitrophenol (DNP), another miracle weight loss pill that converted stored calories to heat.

Works great up until it literally cooks you to death.

This new method of converting white fat to brown fat to heat sounds like it's in that same neighborhood.

If it works, cool! But be cautious if you see a bottle of some shit claiming to do this at your local pharmacy.

[+] peopleproblems@lemmy.world 7 points 9 months ago (1 children)

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[–] Krazore@lemmy.world 10 points 9 months ago (1 children)

Not really if you look into the literature. There were several studies done at Stanford and several hundred thousand people that took it for fat loss and less than 100 deaths from what I've seen. Also, a majority of those deaths were from suicide, which is both a sad thing and a terrible way to go. The deadly dose was about 5-6x the normal dose. There was a case of a girl ODing on it to get ready for spring break and I believe she was around 10x the standard dose. Note dosage is based off body weight.

Now there are other issues that can occur because of the MoA it causes you to burn through zinc and magnesium. There are thyroid issues that can occur, as well as the possibility of cataractics. Then there's the proton slip and electron leakage within the mitochondria. This is what causes a majority of the problems as it's a positive feedback loop for negative cascades. That can be almost entirely negated by keeping dose lower and doing your cardio. It can be done safely if you know what you're doing but most people aren't that reasonable.

Someone wrote an interesting book on it and took more of a conspiracy standpoint on it claiming it could be effective fat loss but because it was cheap and easy it would cut into big pharma making money. Can't say I agree with everything in the book but there was some useful information.

There's also a newer compound called BAM-15. In research it's more effective at fat loss and can be taken at much higher doses safely. I believe they got up to 20x the dnp standard dose without negative side effects in the lab rats.

[–] SatouKazuma@lemmy.world 2 points 9 months ago

Tl;dr take your medicines at the prescribed dosages, and consult with a licensed physician before making changes to medical regimens.

[–] mojofrododojo@lemmy.world 3 points 9 months ago (1 children)

coming at a time when temps are going up, permanently (well, for any human lifespan) people eating too much then burning calories to dump as waste heat completely tracks.

[–] Noodle07@lemmy.world 2 points 9 months ago

I take stims everyday and it's hell in summer

[–] Kowowow@lemmy.ca 8 points 9 months ago

I've been wondering for a while if burned fat releases protein as if you had eaten the fat

[–] dylanmorgan@slrpnk.net 6 points 9 months ago

Okay, how do I get my hands on some of the stuff they used so I can inject it into my abdomen?

[–] flop_leash_973@lemmy.world 6 points 9 months ago

Scientists have figured out a ton of things in a lab setting. But most of that is not something that scales up to the real world.

[–] FreeLikeGNU@lemmy.world 3 points 9 months ago

Oily rectal discharge anyone?

[–] obbeel@lemmy.eco.br 2 points 8 months ago

I like the mix of seriousness (serious scientific topic) and sensationalism (fat cells burning calories) in this article.

[–] stupidcasey@lemmy.world 1 points 6 months ago

That sounds dangerous, the whole purpose of fat is to store energy if you’re smoking your own supply you won’t have anything left to sell.