Alright, so the realization I had right at the end of yesterday was that I've forgotten a pair of Refineries. Decided to plop them in next to these 4 in the center, and shifted the entire chunk over to the left, to help some of the piping line up.

With those in place, I was able to finish out most of the logistics work for all these machines in the middle of the facility. That's all the Heavy Oil Residue and Polymer Resin dealt with.

Now, I'm toying with the idea of an elevated central bus of some kind to handle the rest of the logistics work. Still not sure where I want to go with this, design-wise, but I think I'm gonna use this concept of pillar supports.