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Revolution in pain management: first non-opioid drug arrives (hive.blog)

submitted 1 week ago by [email protected] to c/[email protected]

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[–] [email protected] 106 points 1 week ago (2 children)

There's a lot of snark, but the idea is this only inhibits pain in the peripheries, so it isn't so psychoactively impacting. You don't get sedated, the addiction profile is way less, and the LD50 means OD'ing is much harder. I'm sure there's dependency potential, but it seems this is NOT recreational, which is huge, and if the sedation is less and you can take this and still function, it could be a game changer, allowing people impacted by chronic pain to re-enter the work force and have a better quality of life:

https://en.wikipedia.org/wiki/Suzetrigine https://pubmed.ncbi.nlm.nih.gov/39775738/

[–] [email protected] 37 points 1 week ago (1 children)

For a moment I thought there was a drug called Recreationol. It sounded like a hell of a party.

[–] FistingEnthusiast 6 points 1 week ago (1 children)

I'd take it for sure

[–] [email protected] 4 points 1 week ago

A drug that gives you the feeling of bbqing with friends and family in the city park. Lit

[–] [email protected] 6 points 1 week ago (5 children)

allowing people impacted by chronic pain to re-enter the work force

You mean they're just going to force utterly crippled and suffering people to work instead of taking some time to heal in a hospital...

[–] [email protected] 34 points 1 week ago

No, lots of people out there years out from an accident or injury can't work and it leads to the opioid addiction cycle; having an option to control the pain and get people able to either work or do hobbies again, or do things with their families, would be huge.

[–] [email protected] 28 points 1 week ago

Nowhere in their comment did they even come close to implying what you’re suggesting. There are many folk who’d love to go back to doing the things they love, which includes actual work, but can’t, because the hospital did all they could and sent them on their way to deal with crippling pain on their own. This might let those people go back to doing what they love to do.

Stop making shit up.

[–] [email protected] 19 points 1 week ago (1 children)

In what dictionary is allowing a synonym for forcing???

[–] [email protected] 10 points 1 week ago (1 children)

In America.

[–] [email protected] 10 points 1 week ago

Yes yes, we get it. Everything is bad and nothing can be good.

[–] [email protected] 15 points 1 week ago

Not everywhere is the US.

[–] [email protected] 10 points 1 week ago (1 children)

There are multiple conditions that cause pain for no apparent physiological reason.

[–] [email protected] 4 points 1 week ago (1 children)

This. What is a hospital visit going to do about chronic migraines?

[–] [email protected] 3 points 1 week ago

Tbf, I don't think this new drug would do anything about them either, considering it only blocks periferal pain.

[–] [email protected] 17 points 1 week ago

Hopefully it's not addictive, so maybe - just fucking maybe - people actually in pain can get it without jumping through a million hoops and being treated like drug-addicted criminals.

That'd be... neat.

[–] [email protected] 14 points 1 week ago (2 children)

I will bite. How much? Unless its cheaper than opiates, No one is going to put their profit margin above the common good of society.

[–] [email protected] 25 points 1 week ago (1 children)

“Vertex says that the medication will be available for $15.50 per 50-milligram pill, or about $30 per day. In contrast, comparable doses of the hydrocodone and acetaminophen combination retail for an average of about $7 per day.”

https://www.scientificamerican.com/article/what-is-journavx-the-new-opioid-free-painkiller-from-vertex/

[–] [email protected] 20 points 1 week ago* (last edited 1 week ago) (1 children)

Alternative: send Vertex Pharmaceuticals' board to the guillotine and make the medication available for pennies per 50-milligram pill (at cost) or free (publicly funded).

[–] [email protected] 10 points 1 week ago (2 children)

Yes that will get people to do research and make new meds available. /s

[–] [email protected] 22 points 1 week ago* (last edited 1 week ago) (2 children)

Should I have added "nationalize it and make future research funded and owned by the public"? (A lot of public funding already goes to medical research, but the profits get privatized.)

Private corporations researching medications so they can price gouge the chronically ill through a copyright-enforced monopoly isn't the only way to do medical research.

[–] [email protected] 2 points 1 week ago

The public is definitely not benefitting enough from the research they fund als also the price gouging at the cost of sick people is very problematic, but I'm not in favour of beheading bad people. But I understand that the longer decision makers continue to allow these bad people to do these bad things, the more likely it becomes the guillotine makes an appearance.

[–] [email protected] 2 points 1 week ago

That's the way.

[–] [email protected] 8 points 1 week ago

Found the corporate bootlicker.

[–] [email protected] 9 points 1 week ago (1 children)

I think you (unintentionally) have that backwards. The companies absolutely will and do put their profit margin above the common good.

[–] [email protected] 2 points 1 week ago

Yeah…. My bad

[–] [email protected] 7 points 1 week ago (4 children)

significantly more favorable side effect profile

So is this 3 days until an addiction starts vs the usual 2 days? Where’s the deets?

[–] [email protected] 17 points 1 week ago

It does but they didnt explain. It's the reduced impact on a person's brain that makes it less addictive by only blocking pain receptors at periphery locations and not in the brain. Removing the feeling of being high that opiates provide and just numbs the pain.

Journavx, which has been clinically proven to be as effective as opioids in the treatment of acute post-operative pain but with a significantly more favorable side effect profile. The drug blocks pain signals that are only found in the periphery, not in the brain, without the limitations of currently available therapies.

[–] [email protected] 3 points 1 week ago (1 children)

There’s this at the bottom of the article. It may have what you’re looking for.

[–] [email protected] 2 points 1 week ago

I dont see it.

[–] [email protected] 3 points 1 week ago (2 children)

I'll only make your dick fall off (and grow one first if you don't have one)

[–] [email protected] 5 points 1 week ago (1 children)

So it even doubles as non-invasive sex reassigment surgery precursor drug? Damn, this medicine is multifunctional as hell!

[–] [email protected] 1 points 1 week ago

The evolved form of spironolactone

[–] [email protected] 5 points 1 week ago

It's gonna be a huge success with Lemmy users

[–] [email protected] 7 points 1 week ago

What a weird site.

PR releases b/w standard blog fare and meta numbers discussion?

[–] [email protected] 7 points 1 week ago (1 children)

Aspirin has entered chat.

[–] [email protected] 4 points 1 week ago

Ah yes. The mild ache pain slightly less medication.

[–] [email protected] 4 points 1 week ago

Even if it had similar addiction profiles to opioids I'd be all for it. Opioid allergies are very common and those of us who have them also deserve to not be in agony after surgeries or physical trauma.

In fact, I worry that if its nonaddictive it may be pushed onto people who are allergic or nonresponsive to it similar to how nonstimulant adhd meds are. That doesn't mean I'm not all for nonaddictive painkillers, I'm 100% in favor and if we had a few options that can cover our bases I'd be in favor of shelving the poppy juice into a last resort role, but I hope people don't lose their sense of nuance in it.

[–] [email protected] 3 points 1 week ago

This does sound like great news.

[–] [email protected] 3 points 1 week ago

Oh hell no, I’ve been watching Lazarus. I know how this ends.

[–] [email protected] 2 points 1 week ago

Its great! And if you pop the miniature eyes that grow behind your ear in the first month, you don't have to get them surgically removed! A lot of people might think "hmm extra eyes! Heck yeah!" But what they don't get is how weird everything looks from behind. And the blinking! Nobody wants to be behind you and watch you blink. But you just pop them first sight and you'll be happy as a clown!... Clam! Sorry!

[–] [email protected] 2 points 1 week ago

shrugs in stoner

[–] [email protected] 1 points 1 week ago

Is this BBB soluble like gabapentin?